Mechanism of triazolo-benzodiazepine and benzodiazepine action in anxiety and depression: Behavioral studies with concomitant in vivo CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal
Identifieur interne : 001197 ( Main/Exploration ); précédent : 001196; suivant : 001198Mechanism of triazolo-benzodiazepine and benzodiazepine action in anxiety and depression: Behavioral studies with concomitant in vivo CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal
Auteurs : Patricia A. Broderick [États-Unis] ; Omotola Hope [États-Unis] ; Pierrot Jeannot [États-Unis]Source :
- Progress in Neuropsychopharmacology & Biological Psychiatry [ 0278-5846 ] ; 1998.
English descriptors
- Teeft :
- Adinazolam, Adinazolam injection, Alprazolam, Ambulation, Ambulatory, Ambulatory behavior, Anesthesia, Animal control, Animal model, Animal models, Anova, Antidepressant, Baseline, Baseline values, Behavioral, Behavioral activity patterns, Behavioral chamber, Benzodiazepine, Broderick, Bzds, Central ambulations, Chloral, Chloral hydrate, City college, City university, Clin, Data point, Dawley, Diazepam, Diazepam injection, Dopamine, Dorsal raphe, Electrochemical, Endogenous, Endogenous synaptic concentrations, Equal variance, Fine movement behavior, Fine movements, First hour, Gaba, Habituated, Hippocampal, Hippocampal norepinephrine, Hippocampal release, Hippocampus, Hydrate, Locomotor activity, Mgikg, Mgikg dose, Mglkg, Microelectrodes, Microvoltammetry, Minute mark, Monoamine, Montigny, Movement behavior, Neuron, Neuronal, Neurosci, Norepinephrine, Novel environment, Open field behavior, Panic disorder, Pharmacol, Photobeam, Photobeam interruptions, Psychiat, Psychopharmacol, Receptor, Release effects, Reuptake, Second dose, Second hour, Sedative, Sedative properties, Serotonin, Serotonin release, Sethy, Significant difference, Sprague dawley, Sprague dawley rats, Synaptic, Synaptic concentrations, Tbzd, Tbzds, Time course studies, Triazolobenzodiazepine, Unequal, Unequal variance, Variance, Vivo, Vivo electrochemical, Vivo microvoltammetry.
Abstract
Abstract: 1. 1. Real time, in vivo microvoltammetric studies were performed, using miniature carbon-based sensors, to concurrently detect norepinephrine (NE) release and serotonin (5-HT) release, in 2 separate electrochemical signals, within CA1 region of hippocampus in the freely moving and behaving, male, Sprague Dawley laboratory rat. 2. 2. Concurrently, four parameters of open-field Behavior I.E. Ambulations, Rearing, Fine Movements and Central Ambulatory behavior (a measure of anxiety reduction behavior), were assayed by infrared photobeam detection. 3. 3. Time course studies showed that the mechanism of action of the triazolobenzodiazepine (TBZD), adinazolam, (Deracyn®) is dramatically different from that of the classical benzodiazepine (BZD), diazepam (Valium®) i.e., adinazolam increased, whereas diazepam decreased, 5-HT release within CA1 region of hippocampus in the freely moving and behaving rat. 4. 4. Adinazolam initially increased NE release and then decreased NE release in CA1 region of hippocampus in the freely moving and behaving rat whereas diazepam only decreased the electrochemical signal for NE; the decrease in NE produced by adinazolam was greater than the decrease in NE release produced by diazepam. 5. 5. The Behavioral Activity Patterns, derived from same animal controls, simultaneously with detection of in vivo microvoltammetric signals for NE release and 5-HT release, showed that the BZD, diazepam, exhibited more potent sedative properties than did the TBZD adinazolam. 6. 6. Hippocampal 5-HT and NE release effects of the TBZD, adinazolam, concomitant with behavioral effects lends explanation to the dual anxiolytic/antidepressant properties of the TBZDs.
Url:
DOI: 10.1016/S0278-5846(98)00010-4
Affiliations:
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Broderick</name><affiliation></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology and Pharmacology, The City University of New York Medical School, NY, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hope, Omotola" sort="Hope, Omotola" uniqKey="Hope O" first="Omotola" last="Hope">Omotola Hope</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>MARC and MBRS Undergraduate Program, City College of New York, NY, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Jeannot, Pierrot" sort="Jeannot, Pierrot" uniqKey="Jeannot P" first="Pierrot" last="Jeannot">Pierrot Jeannot</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>MARC and MBRS Undergraduate Program, City College of New York, NY, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Progress in Neuropsychopharmacology & Biological Psychiatry</title><title level="j" type="abbrev">PNP</title><idno type="ISSN">0278-5846</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="353">353</biblScope><biblScope unit="page" to="386">386</biblScope></imprint><idno type="ISSN">0278-5846</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0278-5846</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adinazolam</term><term>Adinazolam injection</term><term>Alprazolam</term><term>Ambulation</term><term>Ambulatory</term><term>Ambulatory behavior</term><term>Anesthesia</term><term>Animal control</term><term>Animal model</term><term>Animal models</term><term>Anova</term><term>Antidepressant</term><term>Baseline</term><term>Baseline values</term><term>Behavioral</term><term>Behavioral activity patterns</term><term>Behavioral chamber</term><term>Benzodiazepine</term><term>Broderick</term><term>Bzds</term><term>Central ambulations</term><term>Chloral</term><term>Chloral hydrate</term><term>City college</term><term>City university</term><term>Clin</term><term>Data point</term><term>Dawley</term><term>Diazepam</term><term>Diazepam injection</term><term>Dopamine</term><term>Dorsal raphe</term><term>Electrochemical</term><term>Endogenous</term><term>Endogenous synaptic concentrations</term><term>Equal variance</term><term>Fine movement behavior</term><term>Fine movements</term><term>First hour</term><term>Gaba</term><term>Habituated</term><term>Hippocampal</term><term>Hippocampal norepinephrine</term><term>Hippocampal release</term><term>Hippocampus</term><term>Hydrate</term><term>Locomotor activity</term><term>Mgikg</term><term>Mgikg dose</term><term>Mglkg</term><term>Microelectrodes</term><term>Microvoltammetry</term><term>Minute mark</term><term>Monoamine</term><term>Montigny</term><term>Movement behavior</term><term>Neuron</term><term>Neuronal</term><term>Neurosci</term><term>Norepinephrine</term><term>Novel environment</term><term>Open field behavior</term><term>Panic disorder</term><term>Pharmacol</term><term>Photobeam</term><term>Photobeam interruptions</term><term>Psychiat</term><term>Psychopharmacol</term><term>Receptor</term><term>Release effects</term><term>Reuptake</term><term>Second dose</term><term>Second hour</term><term>Sedative</term><term>Sedative properties</term><term>Serotonin</term><term>Serotonin release</term><term>Sethy</term><term>Significant difference</term><term>Sprague dawley</term><term>Sprague dawley rats</term><term>Synaptic</term><term>Synaptic concentrations</term><term>Tbzd</term><term>Tbzds</term><term>Time course studies</term><term>Triazolobenzodiazepine</term><term>Unequal</term><term>Unequal variance</term><term>Variance</term><term>Vivo</term><term>Vivo electrochemical</term><term>Vivo microvoltammetry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: 1. 1. Real time, in vivo microvoltammetric studies were performed, using miniature carbon-based sensors, to concurrently detect norepinephrine (NE) release and serotonin (5-HT) release, in 2 separate electrochemical signals, within CA1 region of hippocampus in the freely moving and behaving, male, Sprague Dawley laboratory rat. 2. 2. Concurrently, four parameters of open-field Behavior I.E. Ambulations, Rearing, Fine Movements and Central Ambulatory behavior (a measure of anxiety reduction behavior), were assayed by infrared photobeam detection. 3. 3. Time course studies showed that the mechanism of action of the triazolobenzodiazepine (TBZD), adinazolam, (Deracyn®) is dramatically different from that of the classical benzodiazepine (BZD), diazepam (Valium®) i.e., adinazolam increased, whereas diazepam decreased, 5-HT release within CA1 region of hippocampus in the freely moving and behaving rat. 4. 4. Adinazolam initially increased NE release and then decreased NE release in CA1 region of hippocampus in the freely moving and behaving rat whereas diazepam only decreased the electrochemical signal for NE; the decrease in NE produced by adinazolam was greater than the decrease in NE release produced by diazepam. 5. 5. The Behavioral Activity Patterns, derived from same animal controls, simultaneously with detection of in vivo microvoltammetric signals for NE release and 5-HT release, showed that the BZD, diazepam, exhibited more potent sedative properties than did the TBZD adinazolam. 6. 6. Hippocampal 5-HT and NE release effects of the TBZD, adinazolam, concomitant with behavioral effects lends explanation to the dual anxiolytic/antidepressant properties of the TBZDs.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Broderick, Patricia A" sort="Broderick, Patricia A" uniqKey="Broderick P" first="Patricia A." last="Broderick">Patricia A. Broderick</name></region><name sortKey="Hope, Omotola" sort="Hope, Omotola" uniqKey="Hope O" first="Omotola" last="Hope">Omotola Hope</name><name sortKey="Jeannot, Pierrot" sort="Jeannot, Pierrot" uniqKey="Jeannot P" first="Pierrot" last="Jeannot">Pierrot Jeannot</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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